What’s the TLC- NOSF ?
TLC-NOSF is a new combination of the patented lipido-colloid technology (TLC) with a new compound NOSF.
NOSF is an innovative compound derived from the chemical oligosaccharide family, specially selected by Laboraoitres URGO research department, having demonstrated Matrix Metalloproteinase inhibiting properties and its clinical efficacy in terms of retriggering the healing in chronic leg ulcers with a delay in healing process. It combined with a lipido-colloid TLC matrix (Urgotul Start) or an absorbent lipido-colloid TLC matrix.
HOW DOES IT WORK ?
In contrast with the pattern of balance and control between MMPs and growth factors during normal healing process, an increase in proteinase activity is a factor systematically described in stagnant chronic wounds demonstrating delayed healing. This proteinase hyperactivity is a reflection of persistent inflammation, preventing progress to the proliferative tissue reconstruction phase.
Wounds are subject to continuous exudate flows. The polysaccharide structure of NOSF partially dissolves to form a colloidal substance capable of binding onto all the surfaces of the wound. NOSF also interacts with the metalloproteinases present in the exudate in this micro-environment, reducing their quantity and inhibiting their detrimental activity obstructing healing.
The TLC matrix, the vector for diffusion of NOSF, maintains a moist environment in the wound, fostering the healing process and the free circulation of growth factors. This inhibition of proteolytic activity with respect to the components of the ECM restores the metabolic balance within the wound and promotes growth factors.
The mobilisation / multiplication of dermal fibroblasts is possible once more, accompanied by a resumption of their new matrix component synthesis activity, enabling dermal granulation to be retriggered.
Advantages
- Re-trigger the wound healing process
- Maintain the moist environment necessary for the healing process
- Establish the soft contact with wound and surrounding skin