URGO MEDICAL

1. GIPPS STUDY (Geriatric Incidence and Prevention of Pressure Sores)

This is the largest prospective multicentre incidence study on the prevention of pressure ulcers in geriatric hospital wards. The objectives of this study were to observe the incidence of the development of pressure ulcers in elderly patients and to assess the impact of local preventive protocols on pressure ulcer development. This study was conducted in 36 hospital geriatric departments following the French National Recommendations issued from the Consensus Conference for pressure ulcer prevention. 1,121 elderly patients at high risk and very high risk of pressure ulcer development were followed-up for 8 weeks on a weekly basis. At the end of the 2-month follow-up period 15,7% of the patients had developed a pressure ulcer.
Pressure ulcers appeared with an incidence of 10,6% on the pelvic area, 7,1% on the heel and 2% on both areas. This incidence was significantly higher in patients presenting mixed incontinence or with a very high risk of pressure ulcer development.

The results of this first observational study conducted in the field of pressure ulcer prevention suggest that Sanyrène® (corpitolinol 60) can reduce the incidence level of pelvic pressure ulcers, when combined with conventional pressure ulcer prevention measures. This topical agent should therefore be included in pressure ulcer prevention protocols for the elderly.

 

 

 

 

References

• Meaume S, Colin D, Barrois B, Allaert F.A. Preventing the occurrence of pressure ulceration in hospitalised elderly patients. Journal of Wound Care. 2005. 2 (14) : 78 - 82

2. Biometrological evaluation of topical application of hyper-oxygenated essential fatty acids (Sanyrène®) on skin integrity

This fundamental randomised, comparative study was carried out in 10 healthy volunteers. The goal was to demonstrate the efficacy of topical application of Sanyrène® (corpitolinol 60) on stratum corneum integrity and barrier function in elderly people. Sanyrène® (corpitolinol 60) was applied on one forearm for 21 days (3 applications per day) and the other arm was used as control. The evaluation criteria were hydration of the skin using a clinical scaling score, measurement of a transepidermal water loss of skin hydration index. The results revealed a positive effect of treatment with Sanyrène® (corpitolinol 60) in the treated areas with a significant decrease of cutaneous clinical scaling, a significant increase of transepidermal water loss, increase of hydration of stratum corneum and significant increase of friction coefficient. This assessment of the effects of Sanyrène® on functional skin parameters adds to our knowledge of the disorders involved in skin breakdown in the elderly and leads us to believe that Sanyrène® (corpitolinol 60) really does improve skin integrity.

 

 

3. An evaluation of hyper-oxygenated fatty acid esters (Sanyrène®) in pressure ulcer management

The aim of this study was to use transcutaneous oxygen pressure (TcpO2) measurements to evaluate the efficacy of a solution containing hyper-oxygenated fatty acids esters Sanyrène® (corpitolinol 60) in the prevention of pressure ulcers. This was an open comparative study approved by a French Medical Ethics Committee. 28 volunteers at risk of developing pressure ulcers, assessed using the Norton scale, were enrolled in this trial. Measurements were taken using a monitor (Microgas 7640, Kontron Instruments) providing a direct reading of TcpO2, expressed in mmHg.

The statistical analysis indicates a significant difference between TcpO2 values during pressure exertion before and after application of Sanyrène® (corpitolinol 60). Oxygen pressure values fell significantly when the patient applied pressure to the sacral area before Sanyrène® was applied whereas no difference in oxygen pressure values was noted after application. Measurement of transcutaneous oxygen pressure is a reliable method that has been used to demonstrate the efficacy of a solution containing hyper-oxygenated fatty acid esters (Sanyrène®) in patients at risk of developing pressure ulcers.
References :

 

 

 

• Colin D, Chomard D, Bois C, Saumet JL. Etude de l’efficacité de Sanyrène® dans la prévention de l’escarre au moyen de la mesure de pression d’oxygène transcutanée. SOINS. 1997. 620 : 1 - 4
• Colin D, Chomard D, Saumet JL, Desvaux B, Marie M. An evaluation of hyper-oxygenated fatty acid esters in pressure sore management. Journal of Wound Care. 1998. 7 (2) : 71 - 72.
• Segovia Gomez T, Bermejo Martinez M, Molina Silva R, Rueda Lopez J, Torra i Bou JE. Cuidado de la piel y ulceras por presion. ROL Enf . 2001. 24 (9) : 578 - 582
• Segovia Gomez T, Bermejo Martinez M, Molina Silva R, Rueda Lopez J, Torra i Bou JE. Cuidado de la piel y ulceras por presion. ROL Enf . 2001. 24 (9) : 578 - 582
• Elkhyat A, Mac Mary S, Degouy A, Creidi P, Marie M, Humbert Ph. Evaluation biométrologique des effets de l’huile hyperoxygénée Sanyrène® sur
  la peau. Journal des Plaies et Cicatrisations. 2003.
  37 (VIII) : 115 - 118

 

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